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                           December 22, 2022

       Angela Chen
       Vice President, Legal
       LianBio
       103 Carnegie Center Drive, Suite 309
       Princeton, NJ 08540

                                                        Re: LianBio
                                                            Amendment No. 1 to
Registration Statement on Form S-3
                                                            Filed December 9,
2022
                                                            File No. 333-268317

       Dear Angela Chen:

             We have reviewed your amended registration statement and have the
following
       comments. In some of our comments, we may ask you to provide us with
information so we
       may better understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.
Unless we note
       otherwise, our references to prior comments are to comments in our
November 28, 2022 letter.

       Amendment No. 1 to Registration Statement on Form S-3

       Cover Page

   1.                                                   We note your revisions
in response to prior comment 1. Please disclose prominently on
                                                        the prospectus cover
page that you are not a Chinese operating company but a Cayman
                                                        Islands holding company
with operations conducted by your subsidiaries.
   2.                                                   We note your revisions
in response to prior comment 5. On the Cover Page, please
                                                        provide a
cross-reference to the consolidated financial statements.
 Angela Chen
FirstName
LianBio LastNameAngela Chen
Comapany22,
December  NameLianBio
              2022
December
Page 2    22, 2022 Page 2
FirstName LastName
       Please contact Jimmy McNamara at 202-551-7349 or Joe McCann at
202-551-6262 with
any questions.



                                                      Sincerely,

                                                      Division of Corporation
Finance
                                                      Office of Life Sciences
cc:      Thomas J. Danielski